NRF2 Downregulation in Oligodendrocytes as a Contributing Cause of Cognitive Decline in Mice
From the abstract
Oligodendrocytes resident in the brain are responsible for maintaining the insulating myelin sheaths around axons that are required for the effective transmission of electrical impulses between neurons. Loss of myelin integrity is the cause of a number of debilitating conditions, but also occurs to some degree with aging. It has been an open question as to how large a contribution this makes to age-related cognitive decline. Researchers here provide evidence for age-related changes in oligodendr
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