Premium
Deep Dives
Extended analysis of longevity's most important topics. 800–1,200 words of evidence, context, and action.
Deep Dives are included in Premium and Ultimate subscriptions.
Subscribe from $10.99/month →The actual evidence on NMN
What 23 studies tell us about nicotinamide mononucleotide supplementation and whether it actually works.
Unlock this deep dive →Why the TAME metformin trial matters
The Targeting Aging with Metformin trial could be the most important longevity study ever run.
Unlock this deep dive →Rapamycin in humans
The evidence, the risks, and the doctors actually prescribing it off-label.
Unlock this deep dive →Zone 2 cardio vs. HIIT
What does the data actually show about different training modalities for longevity?
Unlock this deep dive →Biological age clocks
How they work and whether they're clinically useful for tracking aging.
Unlock this deep dive →Cellular senescence
The zombie cell hypothesis, senolytic drugs, and what the evidence shows.
Unlock this deep dive →The hallmarks update
What the 2023 revision changed and why it matters for longevity research.
Unlock this deep dive →Caloric restriction in humans
The CALERIE trial and what it found about eating less and living longer.
Unlock this deep dive →mTOR inhibition
From rapamycin to rapalogs — what's real vs. hype in the longevity space.
Unlock this deep dive →Epigenetic reprogramming
Yamanaka factors, partial reprogramming, and the risk of cancer.
Unlock this deep dive →