Issues
Issue Archive
Twelve weeks of longevity science, from the hallmarks of aging to supplement evidence.
The Hallmarks of Aging
The 12 root causes, explained simply
What actually causes aging, and what science says we can do about it.
Biological age clocks
What they measure and whether they're useful
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
The actual evidence on NMN/NR supplements
What 23 studies tell us
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Rapamycin
The most interesting longevity drug nobody talks about
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Sleep and lifespan
What the data actually shows
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Cellular senescence
Zombie cells and how to clear them
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
The metformin question
Should healthy people take it?
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Zone 2 cardio
The best anti-aging intervention?
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Caloric restriction vs. time-restricted eating
The evidence
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
mTOR, AMPK, sirtuins
The three longevity pathways explained
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
Partial cellular reprogramming
Yamanaka factors and what's real vs. hype
Opening + Paper + Roundup free · Deep Dive + Verdict for paid
The supplement stack audit
What has real evidence, what doesn't
Opening + Paper + Roundup free · Deep Dive + Verdict for paid