MERKT is Involved in Enabling Microglia to Kill Motor Neurons in ALS
From the abstract
Amyotrophic lateral sclerosis (ALS) is characterized by the loss of motor neurons. Aggregation of TDP-43 is thought to be involved in producing cell death in the brain. Here researchers present evidence in a mouse model of ALS for microglia to destroy motor neurons, and identify key cell surface features that enable this activity. Whether the model is good and this will also be the case in human tissues is the usual question when considering mouse models of neurodegenerative conditions. These mo
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