Bacterial Lipoic Acid Protein Ligase A Improves Mammalian Mitochondrial Function and Health

From the abstract

Here, researchers report on their investigation of gene therapy to introduce a bacterial enzyme, lipoic acid protein ligase A (LplA), into mammals in order to improve mitochondrial metabolism. LplA undertakes lipoylation of proteins, attaching lipoic acid to the protein, and does so somewhat more efficiently than the analogous enzymes in mammals. Lipoylation is known to be involved in the regulation of metabolism, and is largely researched in the context of conditions exhibiting lipoylation defi